Endymion Spring by Matthew Skelton

Endymion Spring is a young man working for Johann Gutenberg in Germany in 1492 when he is inventing his printing press. Johann Fust came to visit and in his possession he had a book - a magic book. The pages were made of dragon skin and it contained secret knowledge of past, present,and future. Endymion Spring opens the book and takes a few of the magic pages.
600 years later, Blake Winters finds these pages in the Bodleian Library in Oxford, England. He can read the riddles contained in the book, but to others, including his sister, Duck, the pages are blank. Blake learns that there is another book - The Last Book and the two parts must be joined. He and his sister decide they must find the Lost Book and return the lost pages, but others in the library world are also searching for the book. The book tells Blake that there is a Person in Shadow who will try to kill him to get the pages. Is it Professor Jolyon Fall, the book expert; Sir Giles Bentley, the book collector; Psalmanazer, the homeless man; or Diana Bentley, Sir Gile's wife. Some of these characters seem to be helping Blake and Duck but can they be trusted?
Great mystery! Both boys and girls would like it. Flashbacks are well marked.

Having reluctantly accompanied his academic mother and pesky younger sister to Oxford, twelve-year-old Blake Winters is at loose ends until he stumbles across an ancient and magical book, secretly brought to England in 1453 by Gutenberg's mute apprentice to save it from evil forces, and which now draws Blake into a dangerous and life-threatening quest. - OCLC

Sneak Peek: "" You've stumbled on to something much larger than you can possibly imagine." "In the dead of night, a cloaked figure drags a heavy box through snow-covered streets. The chest, covered in images of mythical beasts, can only be opened when the fangs of its serpent's-head clasp taste blood. Centuries later, in an Oxford library, a boy touches a strange book and feels something pierce his finger. The volume is blank, wordless, but its paper has fine veins running through it and seems to quiver, as if it's alive. Words begin to appear on the page--words no one but the boy can see. And so unfolds a timeless secret . . . . "From the Hardcover edition.